For this, MPI is used to detect the increase of cerebral blood quantity (CBV) arising from neuroactivation. Within the long perspective, this could doubtlessly allow to study practical neuroactivation on a single-patient level and thus bring functional neuroimaging to clinical diagnostics. The tracers used in magnetic particle imaging (MPI) are superparamagnetic iron oxide nanoparticles (SPIONs). They're composed of a magnetite (Fe3O4) or maghemite (Fe2O3) core surrounded by a surface coating (generally ...